PATHCHAT Edition
Published: 2024
Please contact your local Ampath pathologist for more information.
Role of Electron Microscopy in Renal Histopathology
✅ Why is Electron Microscopy (EM) Essential?
- EM is an integral part of diagnostic renal histopathology.
- Used alongside light microscopy and immunofluorescence studies.
- Provides ultra-high resolution imaging for precise diagnosis.
✅ What Does EM Help Diagnose?
- Glomerular, vascular, and tubulointerstitial disorders.
- Structural changes in kidney diseases that are not visible with standard microscopy.
📌 EM enhances the accuracy of renal biopsy interpretation, aiding in the classification of complex renal diseases.
Key Conditions Where EM is Crucial
✅ Hereditary Glomerular Basement Membrane Disorders
- Thin basement membrane nephropathy.
- Alport syndrome.
✅ Immune Complex-Mediated Glomerulonephritis
- Lupus nephritis.
- Membranous glomerulonephritis.
- Post-infectious glomerulonephritis.
✅ Podocytopathies
- Minimal change disease (MCD) with podocyte foot process effacement.
✅ Deposition Diseases
- Amyloidosis.
- Fibrillary and immunotactoid glomerulopathies.
- Cryoglobulinemia.
✅ Transplant Pathology
- Detection of early chronic antibody-mediated allograft rejection.
📌 EM is indispensable in the classification and confirmation of renal pathology, ensuring accurate diagnosis and targeted management.
Electron Microscopy at Ampath
✅ Advanced Transmission Electron Microscopy (TEM) Services
- In-house ultra-high resolution TEM available.
- Allows for superior imaging and precise renal biopsy evaluation.
✅ Contact for Electron Microscopy Services
- Ampath EM Unit (Lynnwood, Pretoria).
- Phone: 087 087 0200.
- Consult with your local histopathologist for tissue requirements and additional information.
📌 Ampath offers cutting-edge renal biopsy evaluation using advanced electron microscopy techniques.